Embryo Glue

- Researches in the invitro Fertilization aim to improve ovulation induction

techniques, fertilization techniques, culturing media for the embryos and

embryo transfer into the uterus.

- With all the advances in this field implantation of the embryo is still a big

challenge for doctors

• Embryo implantation has several steps:

1- Zona hatching which involves zona pellucida lysis. 2- Apposition of the blastocyst against the endometrium. 3- Then the trophoectoderm start to invade the endometrium in preparation to the formation of the future placenta.

• One of the causes of implantation failure is the inability to form an adhesive material between the blastocyst and the endometrium.

• Embryo Glue is a new culturing media for the embryos to be put in for 10 minutes before transfer into the uterus.

-It helps the embryo in apposition against the endometrium, finding the proper place for implantation, becoming adherent to the endometrium and finally invasion of the trophoectoderm into the endometrium

• The composition of the Glue are: 1- Hyaloronan: which is normally found in the oviduct and uterus and helps in blastocyst adherence into the endometrium. 2- Albumin. 3- Amino acids essential and non essential: both of which are important for blastocyst development and adherence in to the endometrium.

• Embryo glue is associated with increase in Clinical pregnancy rates and implantation rates, especially in these cases: *In women >35 year old. *In women who had poor quality embryo. *In women who had previous implantation failure.